论文部分内容阅读
目的 探讨国人吸烟与帕金森病(PD)的负相关联是否存在剂量效应关系.方法 采用以人群为基础的病例对照研究,调查在北京地区55岁以上PD患病率调查中确诊及2002年8月至2003年1月在北京协和医院帕金森研究中心诊治的患者共114例;以及性别、民族及居住地与其匹配的对照205例.结果 以非吸烟人群为对照,吸烟年限<20a、≥20a;戒烟年限>20a、<20a、现仍吸烟;吸烟量0.5盒/d、>0.5盒/d呈现PD神经保护性增强趋势,OR值分别为0.61(95%CI:0.35,1.07)、0.35(95%CI:0.18,0.70);0.61(95%CI:0.31,1.12)、0.47(95%CI:0.17,1.13)、0.44(95%CI:0.23,0.86);0.54(95%CI:0.33,0.89)、0.53(95%CI:0.12,0.86).结论 吸烟与帕金森病的负相关联存在剂量效应.
Objective To investigate the relationship between smoking and Parkinson’s disease (PD) negative correlation.Methods A population-based case-control study was conducted to investigate the prevalence of PD in people over 55 years of age in Beijing and the prevalence of PD A total of 114 patients were diagnosed and treated in Parkinson’s Research Center, Peking Union Medical College Hospital from January to January 2003. The matched controls of sex, ethnicity and place of residence were 205. Results The smoking duration was less than 20 years ; Smoking cessation period> 20a, <20a, still smoking; smoking 0.5 boxes / d,> 0.5 boxes / d showing PD neuroprotective enhancement trend, OR values were 0.61 (95% CI: 0.35,1.07), 0.35 (95% CI: 0.31, 0.12); 0.47 (95% CI: 0.17, 1.13) 0.89), 0.53 (95% CI: 0.12, 0.86) .Conclusion There is dose effect in the negative correlation between smoking and Parkinson’s disease.