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本文对胎肝细胞输注或全胚注射液治疗再生障碍性贫血的可能机理作了一些实验性探讨。研究结果表明: 1.胎肝细胞在培养或解体过程中释放某些刺激红系造血的因子,有利于已经损伤的造血功能的恢复。 2.对正常小鼠注射无细胞胎肝制剂或全胚注射液后,骨髓红系细胞的分裂指数明显升高,骨髓中粒/红比值趋于降低,反映了骨髓中红系细胞增生活跃的状态。 3.对正常小鼠注射无细胞胎肝制剂或全胚注射液后,外周血网织红细胞和腹腔巨噬细胞的吞噬指数趋于平行增高,其增高程度和持续时间随注射次数的增加而加强。 小鼠注射无细胞胎肝制剂或全胚注射液后,巨噬细胞吞噬指数的增加,反映了巨噬细胞激活,这种作用除了提高机体的非特异性免疫功能,增强机体的抵抗力外,还可能通过巨噬细胞的活化,直接或间接地调控机体红系细胞的增殖,因而,对巨噬细胞在造血调控中的作用以及它在再生障碍性贫血发病机理研究中的意义提出了讨论。
In this paper, some experimental investigations were conducted on the possible mechanism of fetal liver cell transfusion or whole embryo injection in the treatment of aplastic anemia. The results showed that: 1. Fetal liver cells release some factors that stimulate erythroid hematopoiesis during the process of culture or disassembly, which is beneficial to the recovery of already damaged hematopoietic function. 2. After injection of acellular fetal liver or whole embryo injection into normal mice, the mitotic index of erythroid cells in bone marrow was significantly increased, and the ratio of granules to red in bone marrow tends to decrease, reflecting the hyperplasia of erythroid cells in the bone marrow. status. 3. After injection of acellular fetal liver or whole embryonic injection into normal mice, the phagocytic index of peripheral reticulocytes and peritoneal macrophages tends to increase in parallel, and the degree and duration of its increase increase with the increase in the number of injections. . After the mice were injected with acellular fetal liver or whole embryo injection, the macrophage phagocytosis index increased, reflecting the macrophage activation, in addition to improving the body’s non-specific immune function, enhance the body’s resistance, but also The activation of macrophages may directly or indirectly regulate the proliferation of the erythroid cells of the body. Therefore, the role of macrophages in hematopoietic regulation and its significance in the study of the pathogenesis of aplastic anemia are discussed.