作者应用 BALB/ c小鼠 ,评估了鼻腔接种 BCG的保护作用及 Pst S- 1蛋白接种抵御结核杆菌鼻腔攻击的能力。　　 6～ 8周龄雌性 BALB/ c小鼠间隔 2周鼻腔接种 2剂 BCG或 3剂 Pst S- 1 +霍乱毒素 ( CT) ,接种后用结核杆菌 H37Rv株攻击 ,攻击后取小鼠肺和脾进行细菌计数 ,并对肺部 The authors used BALB / c mice to evaluate the protective effect of nasal vaccination against BCG and the ability of Pst S-1 protein vaccination against M. tuberculosis nasal challenge. Six to eight-week-old female BALB / c mice were intranasally inoculated with two doses of BCG or three doses of Pst S-1 + cholera toxin (CT) two weeks after inoculation and challenged with Mycobacterium tuberculosis H37Rv strain. After challenge, Bacteria count, and on the lungs