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感染幽门螺杆菌(Hp)被认为是患胃癌的一个危险因素,但是还不清楚为什么仅有少数Hp感染者形成癌。Hp按菌株表型分为细胞毒素相关基因(CagA)阳性和CagA阴性故对Hp的不同表型与胃癌关系进行研究。 方法:103例胃体或胃窦的肠型或弥漫型癌,其中90例经ELISA法测定Hp抗体阳性。对照组139例中89例为Hp抗体阳性。血清标本是在胃癌诊断之前平均14.2年采取的,所有血清用ELISA法测定CasA IgG抗体,并测定胃蛋白酶原Ⅰ,分析有CagA抗体的Hp感染者和
Infection with Helicobacter pylori (Hp) is considered a risk factor for gastric cancer, but it is unclear why only a few Hp-infected individuals develop cancer. Hp was divided into two cell-toxin-related genes (CagA) and CagA-negative by the phenotype of the strains. Therefore, the relationship between different phenotypes of Hp and gastric cancer was studied. Methods: 103 cases of intestine or diffuse type carcinoma of the stomach or antrum, of which 90 cases were positive for Hp by ELISA. Of the 139 cases in the control group, 89 were positive for Hp antibody. Serum samples were taken at an average of 14.2 years prior to the diagnosis of gastric cancer. All serum samples were assayed by ELISA for CasA IgG antibodies, and assayed for pepsinogen I. H. pneumoniae antibodies with CagA antibodies were analyzed.