论文部分内容阅读
目的:系统评价同时性双侧乳腺癌(SBBC)与异时性双侧乳腺癌(ABBC)预后差异。方法:计算机检索国内外数据库,收集相关文献,经文献筛选、质量评价和资料提取后,对符合纳入标准的研究采用Revman 5.3软件进行Meta分析。结果:共纳入7个研究,共711例患者,其中SBBC患者225例,ABBC患者486例。Meta分析结果显示,SBBC患者组1、5、10年生存率均明显低于ABBC患者(OR=0.41,95%CI=0.22-0.77,P=0.005;OR=0.52,95%CI=0.39~0.69,P<0.00001;OR=0.43,95%CI=0.25-0.74,P=0.003)。结论:在同等医疗条件下,SBBC的预后可能差于ABBC,但仍需作进一步的完整评估。
OBJECTIVE: To systematically evaluate the prognosis of patients with simultaneous bilateral breast cancer (SBBC) and heterogenous bilateral breast cancer (ABBC). Methods: The databases of domestic and abroad were searched by computer and relevant documents were collected. After the documents were screened, the quality evaluation and the data were extracted, Meta-analysis was performed on RevMan 5.3 software which met the inclusion criteria. Results: A total of 711 studies were enrolled in 7 studies, including 225 SBBC patients and 486 ABBC patients. Meta-analysis showed that the 1, 5, 10-year survival rates of SBBC patients were significantly lower than those of ABBC patients (OR = 0.41, 95% CI = 0.22-0.77, P = 0.005; OR = 0.52, 95% CI = 0.39-0.69 , P <0.00001; OR = 0.43, 95% CI = 0.25-0.74, P = 0.003). CONCLUSIONS: SBBC may have a worse prognosis than ABBC under equivalent medical conditions, but further complete evaluation is still needed.