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采用以4-去甲氧基柔红霉素(IDA)为主组成的联合化疗方案,治疗33例初发和复发的急性白血病,其中急性淋巴细胞白血病(ALL)7例,急性非淋巴细胞白血病(ANLL)26例。结果:总有效率70%。初治23例ANLL患者,完全缓解(CR)16例,部分缓解(PR)2例,有效率为79%。5例初治ALL患者,4例CR,1例PR。而复发的2例ALL和3例ANLL患者均未缓解。IDA主要副作用表现为骨髓抑制及心脏毒性。认为以IDA组成联合化疗方案治疗初发的急性白血病具有较好的疗效
Thirty-three patients with initial and recurrent acute leukemia were treated with a combined chemotherapeutic regimen consisting predominately of 4-desmethoxy daunorubicin (IDA), including 7 acute lymphoblastic leukemia (ALL), 7 acute non-lymphocytic leukemia (ANLL) in 26 cases. Results: The total efficiency of 70%. Of 23 newly diagnosed patients with ANLL, complete remission (CR) in 16 cases, partial response (PR) in 2 cases, the effective rate was 79%. 5 cases of newly diagnosed ALL patients, 4 cases of CR, 1 case of PR. The relapse of 2 cases of ALL and 3 cases of ANLL patients were not relieved. The main side effects of IDA are myelosuppression and cardiotoxicity. It is considered that the treatment of acute leukemia with IDA combined with chemotherapy regimen has good curative effect