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已有充分证据表明胰岛素依赖性糖尿病是一种免疫疾病。目前尚不了解此病是因病毒感染还是由自身免疫刺激物所引起,但β细胞的逐渐破坏是免疫介导所致,已无疑问。这种新认识是过去几十年的研究结果,研究证明:(1)在单卵双胞胎中胰岛素依赖型糖尿病的一致率低于50％,因而此病不单纯是由遗传所决定;(2)与HLA D和DR基因有关的遗传决定素质是此病发生的要素;(3)几乎所有新确诊的病人血液中均存在免疫球蛋白(胰岛细胞抗体,IC-
There is good evidence that insulin-dependent diabetes is an immune disease. It is not yet known whether the disease is caused by a viral infection or by an autoimmune stimulus, but the progressive destruction of the beta cells is mediated by immunity and no doubt. This new understanding is the result of decades of research. Studies have shown that: (1) the prevalence of insulin-dependent diabetes in monozygotic twins is less than 50%, and the disease is not determined solely by heredity; (2) Genetic determinants of HLA D and DR genes are essential elements of the disease; (3) Immunoglobulins (islet cell antibodies, IC-