论文部分内容阅读
目的:分析妊娠期急性脂肪肝(acute fatty liver of pregnancy AFLP)的临床表现、实验指标的特点,探讨其临床意义。方法:采用回顾性分析的方法,收集2004年01月年至2013年12月苏州市立医院34例妊娠期急性脂肪肝患者临床资料、实验数据,总结分析其在病情变化中的特点。结果:34例患者均发生在妊娠晚期,以消化道症状为首发症状,终止妊娠前及终止妊娠第二天肌酐(Gr)、谷丙转氨酶(ALT)、乳酸脱氢酶(LDH)明显下降(P<0.05),凝血指标改善、胆红素下降不明显(P>0.05),白细胞较前升高(P<0.05)。结论:终止妊娠是前提,有效的治疗是保障,肝肾功能、凝血异常的改善及胆红素的恢复需时较久,且有时会受其它因素的影响而波动,不利病情的监测,乳酸脱氢酶、白细胞及抗凝血酶III(AT-III)的变化与病情的变化有一致性,前两者联合监测更能反映疾病转归。
Objective: To analyze the clinical manifestations and the characteristics of experimental indicators of acute fatty liver of pregnancy (AFLP) in pregnancy and to explore its clinical significance. Methods: The clinical data and experimental data of 34 patients with acute fatty liver of pregnancy in Suzhou Municipal Hospital from January 2004 to December 2013 were collected retrospectively. The characteristics of the patients in the change of disease were summarized. Results: All the 34 patients occurred in the third trimester of pregnancy. The gastrointestinal symptoms were the first symptom. The creatinine (Gr), alanine aminotransferase (ALT) and lactate dehydrogenase (LDH) were significantly decreased in the second day before termination of pregnancy and termination of pregnancy P <0.05). The indexes of coagulation improved, but there was no obvious decrease of bilirubin (P> 0.05) and the number of leukocytes increased (P <0.05). Conclusions: Termination of pregnancy is the prerequisite, effective treatment is protection, liver and kidney function, improved coagulation abnormalities and bilirubin recovery takes longer, and sometimes affected by other factors and fluctuations, adverse conditions monitoring, lactate off The change of hydrogenase, leukocyte and antithrombin III (AT-III) was consistent with the change of the disease, and the combination of the former two could better reflect the outcome of the disease.