假单胞菌外毒素A(PE)是绿脓杆菌产生的一种66×10~3多聚肽,完整的PE不能进入哺乳动物细胞内,但可通过α_2-巨球蛋白受体/低密度脂蛋白受体相关蛋白(LRP)与之结合。PE经蛋白水解酶裂解成37×10~3片段进入细胞内能使胞浆中的延长因子2无活性而抑制蛋白合成。Furin是一种与枯草芽胞杆菌蛋白酶相似的丝氨酸蛋白酶,并且是广 Pseudomonas exotoxin A (PE) is a 66 × 10 ~ 3 poly peptide produced by Pseudomonas aeruginosa. The intact PE can not enter into mammalian cells, but can pass α 2 -macroglobulin receptor / low density Lipoprotein receptor associated protein (LRP) binds to it. PE proteolytic cleavage into 37 × 10 ~ 3 fragments into the cytoplasm can make the elongation factor 2 in the cytoplasm inactive and inhibit protein synthesis. Furin is a serine protease similar to Bacillus subtilisin and is widely available