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本文研究了槟榔花茶对亚急性酒精性肝损伤是否有辅助保护作用。50只SD雌性大鼠,随机分成5组(乙醇模型对照组、溶剂对照组和低、中、高剂量组)。剂量组经口灌胃受试物,而溶剂对照组和乙醇模型组灌胃蒸馏水。乙醇模型组和低、中、高剂量组持续30 d灌胃受试物4 h后给予10 m L/kg体重的50%乙醇,而溶剂对照组给予等量蒸馏水。然后对血清中ALT、AST、CHO、TBIL、LDL含量进行检测,并取肝脏进行组织病理学检查。结果显示:随槟榔花茶剂量增加,样品各剂量组血清中AST、ALT、CHO、TBIL和LDL值呈下降趋势,其中高剂量组与乙醇模型组间存在显著差异(p<0.05)。组织病理学检查显示:高剂量组能改善肝细胞脂肪变性,且肝脏病理总分显著低于模型对照组(p<0.05)。综上,槟榔花茶对亚急性酒精性肝损伤有辅助保护功能。
This article studies whether Areca nut tea has a secondary protective effect on subacute alcoholic liver injury. Fifty SD female rats were randomly divided into 5 groups (ethanol model control group, solvent control group and low, medium and high dose groups). The dose group was orally administered with the test substance, while the solvent control group and the ethanol model group were given distilled water. The model group and the low, medium and high dose groups were administered with 10 m L / kg body weight of 50% ethanol for 4 h after 30 d of intragastric administration of the test substance, while the solvent control group was given the same amount of distilled water. Then the serum ALT, AST, CHO, TBIL, LDL content were detected, and take the liver for histopathological examination. The results showed that the AST, ALT, CHO, TBIL and LDL levels of serum decreased with the increase of the amount of camellia tea. There was a significant difference (p <0.05) between the high dose group and the ethanol model group. Histopathological examination showed that high dose group could improve hepatic steatosis, and liver pathology score was significantly lower than the model control group (p <0.05). In summary, areca nut tea on the subacute alcoholic liver injury have an auxiliary protective function.