恶性脑胶质瘤治疗困难,死亡率高。近十年来发展的大剂量化疗联合外周造血干细胞移植治疗恶性脑胶质瘤取得了一些疗效,特别对髓母细胞瘤、原发性神经外胚层肿瘤和高级别的星型细胞瘤有较好的效果。目前所用的治疗方案,大部分是单一的大剂量双氯乙基亚硝脲的治疗方案(800-1000 mg/m2),另有一些多药组合方案,但大剂量方案引起了较多的不良反应,而并未显著提高患者的平均生存时间,故仍需新的药物和方案进行临床试验。 Malignant glioma treatment difficult, high mortality. The development of high-dose chemotherapy in recent decade combined with peripheral blood stem cell transplantation for the treatment of malignant glioma has made some curative effects, especially for medulloblastoma, primary neuroectodermal tumors and high-grade astrocytoma has better effect. Most of the current treatment options are single high dose diclofenac sodium regimen (800-1000 mg / m2) and some multidrug combination regimens, but the high dose regimen causes more adverse effects Response, and did not significantly improve the average survival time of patients, so still need new drugs and programs for clinical trials.