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目的:探讨硝普钠对冠心病心力衰竭患者血浆脑钠肽浓度的影响。方法:将96例冠心病心力衰竭患者随机分为试验组和对照组,试验组在常规基础治疗基础上加用硝普钠,对照组为在常规基础治疗基础上加用小剂量硝酸甘油,疗程7 d,分别测定用药前后血浆脑钠肽浓度。结果:用药后2组患者血浆脑钠肽浓度都有所降低,试验组较对照组显著降低,差异有统计学意义(P<0.05)。结论:硝普钠可显著降低冠心病心力衰竭患者血浆脑钠肽浓度,可作为冠心病心力衰竭患者的选择药物。
Objective: To investigate the effect of sodium nitroprusside on plasma brain natriuretic peptide in patients with coronary heart disease and heart failure. Methods: 96 cases of CHD patients with heart failure were randomly divided into experimental group and control group. The experimental group was given sodium nitroprusside on the basis of routine basic treatment. The control group was given a small dose of nitroglycerin on the basis of routine basic treatment. 7 d, were measured before and after treatment of plasma brain natriuretic peptide. Results: The concentration of plasma brain natriuretic peptide decreased after treatment in both groups, and the experimental group was significantly lower than that of the control group (P <0.05). Conclusion: Sodium nitroprusside can significantly reduce the concentration of plasma brain natriuretic peptide in patients with heart failure of coronary heart disease, which can be used as the choice drug in patients with heart failure of coronary heart disease.