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洋地黄是目前应用很广的一种作用于心脏的药物,自1776年英国医师 Withering 发现其对心脏的特殊的作用以后(5),直到现在,仍不失为临床应用上的一种重要药物。洋地黄叶及其制剂,性质不很安定,久置往往降低效阶,因此必需每隔一年检验一次(7).否则常常发生洋地黄效价不足的情况,在我们实验室里,曾发现过甚至不足标明效价的一半。洋地黄制剂要达到足够疗效的剂量,是接近于中毒量的(10)。因此为了保证临床上应用洋地黄的安全与保证其确实的疗效,进行严格的效价测定是非常必要的。
Digitalis is currently a widely used cardio-therapeutic drug. Since the discovery by the British physician Withering in 1776 of its special effects on the heart (5), up to now, it remains an important drug for clinical application. Digitalis leaves and their formulations, the nature is not very stable, long set tends to reduce efficiency, it is necessary to test once every other year (7), otherwise often occur digitalis yellowing situation, in our laboratory, we found Halfway or even less than half the price. Digitalis preparations to achieve sufficient efficacy dose, is close to the amount of poisoning (10). Therefore, in order to ensure the clinical application of digitalis security and ensure its true efficacy, the stringent determination of potency is very necessary.