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目的了解桂林市2014年1~29岁人群HBs Ag流行率、HBV感染率及抗乙肝病毒表面抗原抗体(Antibody to HBs Ag,HBs Ab)水平,为评估“十二·五”乙肝防控目标完成情况提供参考数据,并为完善乙肝疫苗策略提供科学依据。方法对桂林市秀峰区2个乙型病毒性肝炎血清流行病学监测点共286人开展现场流行病学调查,并采集血样进行HBV血清学指标检测。结果 286份样本中,HBs Ag阳性0人,HBV感染阳性21人,阳性率为7.3%;HBs Ab阳性187人,阳性率为65.4%,不同年龄组阳性率差异有统计学意义(P<0.01)。乙肝五项全阴人数78人,阴性率为27.3%,其中1~4岁年龄组阴性率为15%,5~14岁为40.2%,15~29岁为26.2%,各年龄组全阴率差异无统计学意义(P>0.05)。结论桂林市1~29岁人群乙肝感染率处于较低的水平,感染者主要集中在15~29岁人群;HBs Ab阳性率不高,阳性者主要集中在1~4岁人群;1~4岁人群仍有相当一部分乙肝五项全阴者,对这部分免疫无应答或弱应答者应尽快进行重种。
Objective To investigate the prevalence of HBsAg, HBV infection and anti-HBsAg levels in Guilin from January to 29, 2014. To evaluate the efficacy and safety of hepatitis B control Target completion to provide reference data, and to provide a scientific basis for improving hepatitis B vaccine strategy. Methods A total of 286 people from 2 epidemic stations of hepatitis B in Xiufeng District of Guilin City were enrolled in the epidemiological survey. Blood samples were collected for HBV serological tests. Results The positive rate of HBs Ag in positive samples was 187 (positive rate was 65.4%) in 286 samples, and the positive rate was 7.3%. The positive rate of HBsAg in different age groups was statistically significant (P <0.01) ). The total number of five all-negative hepatitis B patients was 78, the negative rate was 27.3%, of which 1 to 4 years old group negative rate of 15%, 5 to 14 years old was 40.2%, 15 to 29 years old was 26.2% The difference was not statistically significant (P> 0.05). Conclusion The prevalence of hepatitis B in the population of 1- 29 years old in Guilin is low, with the majority of those infected being in the age group of 15-29. The positive rate of HBs Ab is not high. The positive rate of HBs Ab is mainly in the population of 1-4 years old and 1-4 years There are still a considerable portion of the population of hepatitis B five all Yin, no response to this part of the immune response or weak responders should be replanted as soon as possible.