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目的探讨与研究食管癌根治术后放射治疗的临床疗效。方法选自2002年3月至2006年3月来我院就诊的115例食管癌根治术后患者为研究对象,将其随机分为对照组与治疗组两组,对照组(n=48)给予单纯手术治疗,治疗组(n=67)给予放射治疗,比较两组局部控制率、生存率。结果治疗结束后4周,治疗组完全缓解34例,部分缓解25例,无变化6例,病变进展2例,有效率为88.06%;对照组完全缓解13例,部分缓解19例,无变化11例,病变进展5例,有效率为66.67%;两组局部控制率经比较(χ2=10.09,P<0.05)差异有统计学意义。治疗组1、3、5年生存率分别为76.12%、52.24%、38.81%;对照组1、3、5年生存率分别为66.67%、39.58%、20.83%。两组1、3、5年生存率经比较(χ2=1.24,>0.05;χ2=1.80,P>0.05;χ2=4.20,P<0.05)。结果显示两组5年生存率经比较具有统计学差异。5年后两组Ⅱ期生存率经比较,P<0.05差异有统计学意义。结论食管癌根治术后放射治疗可减少局部复发,提高远期生存率。
Objective To study and study the clinical effect of radiotherapy after radical resection of esophageal cancer. Methods A total of 115 patients with esophageal cancer undergoing radical resection from March 2002 to March 2006 in our hospital were randomly divided into control group and treatment group, and control group (n = 48) Simple surgical treatment, the treatment group (n = 67) given radiotherapy, compared two groups of local control rate, survival rate. Results 4 weeks after the end of treatment, the treatment group completely relieved 34 cases, partial remission in 25 cases, no change in 6 cases, pathological changes in 2 cases, the effective rate was 88.06%; control group, complete remission in 13 cases, partial remission in 19 cases, no change in 11 cases Cases, the progress of the disease in 5 cases, the effective rate was 66.67%; two groups of local control rate by comparison (χ2 = 10.09, P <0.05), the difference was statistically significant. The 1, 3, 5-year survival rates of the treatment group were 76.12%, 52.24% and 38.81%, respectively. The 1, 3, 5-year survival rates of the control group were 66.67%, 39.58% and 20.83%, respectively. The 1, 3, 5-year survival rates of two groups were compared (χ2 = 1.24,> 0.05; χ2 = 1.80, P> 0.05; χ2 = 4.20, P <0.05). The results showed that the two groups of 5-year survival rate was statistically significant difference. After 5 years, the survival rate of the two groups was compared, P <0.05 was statistically significant. Conclusion Radiotherapy after radical surgery of esophageal cancer can reduce the local recurrence and improve the long-term survival rate.