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本文对胰岛素治疗 2型糖尿病 (ＤＭ)是增加还是减少大血管病变的危险进行探讨。一些体外试验表明胰岛素能促使脂质进入动脉粥样硬化斑 ,引起内膜增生。提出在非ＤＭ或ＤＭ前期 ,血清胰岛素升高 (高胰岛素血症或胰岛素抵抗 )与心血管病 (ＣＶＤ)发病率增加有关。ＤＭ控制不当的
This article examines whether insulin in the treatment of type 2 diabetes mellitus (DM) increases or decreases the risk of macrovascular disease. Some in vitro tests show that insulin can promote lipid into atherosclerotic plaque, causing intimal hyperplasia. It is suggested that elevated serum insulin (hyperinsulinemia or insulin resistance) may be associated with an increased incidence of cardiovascular disease (CVD) in non-DM or DM prophase. Improper DM control