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目的了解钙离子拮抗剂致心脏不良反应(ADR)的发生情况,探讨其发生规律,指导临床合理用药,保证用药安全有效。方法对河南省2004-2012年上报的63例钙离子拮抗剂发生的药品不良反应进行统计分析。结果心脏ADR的发生与性别关系不大,与年龄关系密切,41岁以上的中老年患者居多;ADR发生时间多集中在1d内;临床表现以心悸、心律失常、心脏骤停、心动过速和房室传导阻滞为主,心悸构成比例最高(76.19%);怀疑药品的剂型以普通片比例最高(58.73%)。结论应加强重视高血压患者的ADR监测工作,为钙离子拮抗剂的合理应用提供依据,降低ADR的发生率。
Objective To understand the occurrence of cardiac adverse reactions (ADRs) induced by calcium ion antagonists, to explore its occurrence, to guide clinical rational use of drugs and to ensure the safe and effective use of drugs. Methods Sixty-three cases of calcium channel blockers reported in Henan Province from 2004 to 2012 were analyzed statistically. Results The incidence of ADR in the heart was not related to gender, and was closely related to age. The incidence of ADR was mostly in the middle-aged and the elderly over 41 years of age. The clinical manifestations included palpitations, arrhythmias, cardiac arrest, tachycardia and Atrioventricular block, heart palpitations constitute the highest proportion (76.19%); suspected drug formulations in the highest proportion of ordinary tablets (58.73%). Conclusion We should pay more attention to the monitoring of ADR in hypertensive patients, provide the basis for the rational application of calcium ion antagonists and reduce the incidence of ADR.