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采用现代核磁共振技术 ,通过分析灌胃给药 0 .0 1、0 .0 5、0 .2、2、10和 10 0mg/kg剂量Lu(NO3 ) 3 2 4h内大鼠尿液及 2 4h后大鼠血清的核磁共振氢谱 (1HNMR) ,由体液中内源性代谢物浓度的变化研究了稀土化合物在动物体内急性毒性。较高剂量组体液中的氨基酸、尿囊素、柠檬酸、氮氧三甲胺和肌酸酐等重要内源性代谢物的核磁共振谱峰强度发生了明显的变化 ,说明动物体内的代谢物出现异常 :高剂量的稀土的引入可能使动物肾脏和肝脏均受到损害 ,且受损程度随稀土剂量的增高而渐趋严重。
Using modern nuclear magnetic resonance technology, through the analysis of intragastric administration of 0 .0 1, 0. 0 5,0 .2,2,10 and 10 0mg / kg dose of Lu (NO3) 3 4h urine of rats and 2 4h The 1H NMR of the rat serum was used to study the acute toxicity of rare earth compounds in animals by the changes of endogenous metabolites in body fluids. Significant changes in the NMR peak intensities of important endogenous metabolites such as amino acids, allantoin, citric acid, triamcinolone, and creatinine were observed in the higher doses of body fluids, indicating abnormalities in metabolites in animals : The introduction of high doses of rare earth may cause damage to the kidneys and liver of animals, and the degree of damage with increasing doses of rare earth is getting worse.