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本文作者对33例慢性B淋巴细胞白血病(B-CLL)患者作连续的细胞遗传学随访研究,发现B-CLL的核型稳定。 33例中21例随访两年以上,其中11例随访5年,3例随访10年另外12例作了1次以上的核型研究但随访不足2年。通常每年1次,如病情进展则作更多次的研究。结果发现14例患者有克隆性染色体异常,与其他作者报导一致,最常见的异常是12号三体和累及14q32的易位。在随访两年以上的21例患者中,10例患者存在核型异常克隆,13例因病情恶化而接受化疗,死亡的7例中5例直接死于白
The authors conducted a continuous cytogenetic follow-up study of 33 patients with chronic B-cell lymphocytic leukemia (B-CLL) and found that the karyotype of B-CLL was stable. Twenty-one of the 33 patients were followed up for more than two years, of whom 11 were followed up for 5 years, 3 were followed up for 10 years and another 12 had more than one karyotype but were followed up for less than 2 years. Usually once a year, more progress should be made as the condition progresses. Fourteen patients had clonal chromosomal abnormalities, consistent with reports by other authors. The most common abnormalities were trisomy 12 and the translocation involving 14q32. Among the 21 patients who were followed up for more than two years, 10 patients had abnormal karyotyping clones, 13 patients received chemotherapy due to the deteriorating condition, and 5 of the 7 death patients died directly from white