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目的对有上消化道症状的患儿进行幽门螺杆菌感染相关研究。方法 2007年6月-2011年12月因上消化道症状来院治疗的患儿共348例分为:A组(<6岁)41例,B组(6～9岁)101例,C组(9～12岁)115例,D组(>12岁)91例。所有患者均行电子胃镜检查,并取活检行细菌培养及病理切片。结果 H.pylori阳性率为52.6%。H.pylori阳性组炎性活动性发生率高于H.pylori阴性组,差异有统计学意义(χ2=103.013,P=0.000)。H.pylori阳性组炎症活动程度集中在轻、中度,而H.pylori阴性组则主要集中在轻度。H.pylori阳性组胃黏膜炎症以中度为主,H.pylori阴性组胃黏膜炎症以轻、中度为主。结论儿童时期是H.pylori的易感期,应尽早诊断和治疗儿童H.pylori感染。
Objective To study the correlation between Helicobacter pylori infection in children with upper gastrointestinal symptoms. Methods From June 2007 to December 2011, 348 children admitted to hospital for treatment of upper gastrointestinal symptoms were divided into group A (n = 41), group B (n = 6 to 101), group C 115 cases of 9 ~ 12 years old, 91 cases of D group (> 12 years old). All patients underwent electronic gastroscopy and biopsy bacterial culture and biopsy. Results The positive rate of H.pylori was 52.6%. The incidence of inflammatory activity in H.pylori positive group was higher than that in H.pylori negative group (χ2 = 103.013, P = 0.000). The degree of inflammatory activity in H.pylori-positive group was mild and moderate, while that in H.pylori-negative group was mainly mild. H.pylori-positive gastric mucosal inflammation was moderately predominant, while H.pylori negative gastric mucosal inflammation was mild and moderately predominant. Conclusion Childhood is a predisposing period to H.pylori. H.pylori infection should be diagnosed and treated as soon as possible in children.