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目的:探讨乳腺甲氧基乙丁基异腈亲肿瘤显像与乳腺癌P-糖蛋白和拓扑异构酶Ⅱ的关系。方法:对76例未行治疗的乳腺癌患者进行99mTc-甲氧基乙丁基异腈显像,采集早期显像(10min)及延迟显像(180min)两时相的平面像,计算放射性清除率;术后标本病理检查采用免疫组化方法进行P-糖蛋白、拓扑异构酶II检测。结果:P-糖蛋白阳性组清除率明显高于阴性组,差异有统计学意义;TopoⅡ表达率与清除率无明显关系。结论:99mTc-甲氧基乙丁基异腈亲肿瘤显像可作为乳腺癌P-糖蛋白无创伤、非组织学测定方法,预测化疗耐药性,指导个性化化疗方案的选择。
OBJECTIVE: To investigate the relationship between breast methoxyethane isonitrile (ONC) tumor imaging and P-glycoprotein and topoisomerase Ⅱ in breast cancer. Methods: Totally 76 cases of untreated breast cancer patients underwent 99mTc-methoxyethylbutyl isonitrile imaging. The plane images of the two phases of early imaging (10 minutes) and delayed imaging (180 minutes) were collected to calculate radioactive clearance rate. Pathological examination of postoperative specimens using immunohistochemical detection of P-glycoprotein, topoisomerase II. Results: The clearance rate of P-glycoprotein positive group was significantly higher than that of negative group, the difference was statistically significant. There was no significant relationship between Topo Ⅱ expression and clearance rate. CONCLUSION: 99mTc-methoxyethylbutynonitrile oncocytoma imaging can be used as a non-invasive and non-histological method for detecting P-glycoprotein in breast cancer. It can predict chemoresistance of chemotherapy and guide the selection of personalized chemotherapy regimens.