【摘 要】
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Objective:To compare the angiogenesis behaviors of vascular endothelial growth factor (VEGF)and Chinese medicine Xuefu Zhuyu Decoction(血府逐瘀汤,XZD) treatments.Methods:Human microvascular endothelial cells (HMEC-1) were treated with various concentrations of
【机 构】
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College of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou(350122),
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Objective:To compare the angiogenesis behaviors of vascular endothelial growth factor (VEGF)and Chinese medicine Xuefu Zhuyu Decoction(血府逐瘀汤,XZD) treatments.Methods:Human microvascular endothelial cells (HMEC-1) were treated with various concentrations of either XZD-containing serum (XZD-CS)or VEGF for 24,48,and 72 h,respectively.Cell viability,proliferation,migration,adhesion,and in vitro tube formation assays were used to assess their angiogenic effects.Results:VEGF promoted all cellular phases involved in angiogenesis including cell viability,proliferation,migration,adhesion,and tube formation (P＜0.05 or P＜0.01).Unlike the continuous promotion effects of VEGF at the above stages,XZD inhibited cell viability and proliferation (P＜0.05 or P＜0.01) and only promoted tube formation in the early phase of angiogenesis (P＜0.01).Conclusions:These two medications promote different angiogenesis behaviors,which might be an important reason for their distinct therapeutic profile in clinical usage.
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