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目的探讨平均血小板体积(MPV)对2型糖尿病肾损伤的临床价值。方法选择本院2014年1月-2015年6月内分泌科收治的2型糖尿病患者355例,根据内生肌酐清除率(Ccr)分为4组:组1:Ccr≥90 ml/min(95例);组2:60 ml/min≤Ccr<90 ml/min(90例);组3:30 ml/min≤Ccr<60 ml/min(88例);组4:Ccr<30 ml/min(82例)。所有受试者均检测MPV等相关指标水平,比较组间差异,并统计MPV与有关指标的相关性。结果 DN相关指标水平比较,4组间年龄、FPG、Hb A1c、BUN、CREA、UA比较,差异均具有统计学意义(P<0.05),有差异的项目组间两两比较,只有BUN检测结果各组间差异具有统计学意义(P<0.05),且随Ccr降低而升高。血小板参数水平比较,4组间MPV和PLT差异具有统计学意义(P<0.05),有差异的项目组间两两比较,只有MPV检测结果各组间差异具有统计学意义(P<0.05),且随Ccr降低而升高。MPV与BUN、CREA、UA存在正相关(P<0.05)。结论 MPV可以较早的反映2型糖尿病肾损伤,其水平高低与损伤的严重程度成正比。
Objective To investigate the clinical value of mean platelet volume (MPV) on type 2 diabetic renal injury. Methods A total of 355 patients with type 2 diabetes admitted to Department of Endocrinology from January 2014 to June 2015 in our hospital were divided into 4 groups according to the endogenous creatinine clearance rate (Ccr): Group 1: Ccr≥90 ml / min (95 cases ); Group 2: 60 ml / min≤Ccr <90 ml / min (Group 90); Group 3:30 ml / min≤Ccr <60 ml / 82 cases). All subjects were detected MPV and other related indicators, comparing the differences between groups, and statistics MPV correlation with the relevant indicators. Results There were significant differences in DN-related indicators between the four groups in age, FPG, Hb A1c, BUN, CREA, UA (P <0.05) The difference between each group was statistically significant (P <0.05), and with Ccr decreased and increased. There were significant differences in MPV and PLT between the four groups (P <0.05). There was significant difference between the two groups (P <0.05) And increased as Ccr decreased. There was a positive correlation between MPV and BUN, CREA and UA (P <0.05). Conclusion MPV can reflect the type 2 diabetic renal injury earlier, the level is proportional to the severity of the injury.