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目的 :研究 2型糖尿病患者微量白蛋白尿与动态血压、胰岛素水平之间的关系。方法 :5 0例 2型糖尿病患者分成微量蛋白尿组 ( 2 3例 ) ,正常蛋白尿组 ( 2 7例 ) ,分别测 2 4小时动态血压、糖基化血红蛋白、胆固醇、甘油三酯、血浆胰岛素水平。结果 :①微量白蛋白尿组患者的夜间收缩压、平均动脉压分别为 ( 14 1.8± 6.8)mmHg( 1mmHg =0 .13 3kPa)和( 97.1± 0 .9)mmHg ,较正常组 ( 12 2 .3± 6.1)mmHg和 ( 88.7± 5 .2 )mmHg明显升高 ,并存在显著差异 ( P均 <0 .0 5 )。②微量白蛋白尿组血浆胰岛素水平明显高于正常组 (P <0 .0 5 )。而血脂血糖、糖基化血红蛋白两组无显著差别 (P均 >0 .0 5 )。结论 :2型糖尿病患者微量白蛋白尿与夜间收缩压、平均动脉压及胰岛素水平有显著相关关系。
Objective: To study the relationship between microalbuminuria and ambulatory blood pressure and insulin in type 2 diabetic patients. Methods: Fifty patients with type 2 diabetes were divided into microalbuminuria group (23 cases) and normal proteinuria group (27 cases). Blood pressure, glycosylated hemoglobin, cholesterol, triglyceride, Insulin levels. Results: The nighttime systolic blood pressure and mean arterial pressure in patients with microalbuminuria were (14 1.8 ± 6.8) mmHg (1mmHg = 0.133kPa) and (97.1 ± 0.9) mmHg respectively, which were significantly lower than those in the normal group .3 ± 6.1) mmHg and (88.7 ± 5.2) mmHg were significantly increased, and there was a significant difference (all P <0.05). ② Microalbuminuria plasma insulin levels were significantly higher than the normal group (P <0.05). However, there was no significant difference between the two groups (P> 0.05) in blood lipid and glycosylated hemoglobin. Conclusion: Microalbuminuria in patients with type 2 diabetes has a significant correlation with nocturnal systolic pressure, mean arterial pressure and insulin levels.