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[目的]探讨转录因子KLF6蛋白在人类肝细胞癌(HCC)、肝硬化中发生发展的作用机制。[方法]用免疫组化方法对51例HCC组织、51例癌旁组织、15例肝硬化组织以及10例因良性病变而切除的正常肝组织中的转录因子KLF6进行蛋白检测。[结果]KLF6蛋白阳性表达率在HCC组织、癌旁组织、肝硬化组织、正常肝组织分别为86.3%(44/51)、68.6%(35/51)、26.7%(4/15)、0。KLF6蛋白随着肝病恶化程度的增高而表达增多。KLF6蛋白表达在HCC组织高于癌旁组织(P<0.05),癌旁组织高于肝硬化组织(P<0.01),HCC组织与癌旁组织均显著高于正常肝组织(P<0.01)。KLF6蛋白阳性表达与肝癌分化程度相关(P<0.05)。[结论]KLF6过表达在HCC与肝硬化的发生发展中起重要作用,其作用机制值得进一步研究。
[Objective] To investigate the mechanism of KLF6 protein in human hepatocellular carcinoma (HCC) and cirrhosis. [Method] Immunohistochemical method was used to detect the transcription factor KLF6 in 51 cases of HCC, 51 cases of paracancerous tissues, 15 cases of cirrhosis and 10 cases of normal liver tissue resected due to benign lesions. [Results] The positive expression rates of KLF6 protein in HCC tissues, paracancer tissues, liver cirrhosis tissues and normal liver tissues were 86.3% (44/51), 68.6% (35/51), 26.7% (4/15), 0 . KLF6 protein with increased levels of liver disease and increased expression. The expression of KLF6 protein in HCC tissue was higher than that in paracancer tissue (P <0.05), paracancer tissue was higher than that in cirrhosis (P <0.01), and both HCC and paracancer tissues were significantly higher than those in normal liver tissue (P <0.01). The positive expression of KLF6 protein correlated with the degree of differentiation of HCC (P <0.05). [Conclusion] The overexpression of KLF6 plays an important role in the occurrence and development of HCC and cirrhosis. Its mechanism of action deserves further study.