目的:研究大鼠注射施普睿达注射液后的血药浓度和药动学特征。方法:大鼠尾静脉注射施普睿达注射液低、中、高3个剂量(50,100,200 mg·kg~(-1))后检测不同时间血浆中施普睿达的浓度,并估算其药物动力学参数。结果:大鼠单次静注给予注射用施普睿达后,主要药动学参数t_(1/2)分别为0.43,0.37,0.41 h;AUC_((0～∞))分别为91.12,172.65,280.02 mg·h·L~(-1);C_(max)分别为261.23,433.79,751.22 mg·L~(-1)。结论:该法适于药物动力学考察。大鼠体内注射用施普睿达在50～200 mg剂量范围内呈线性药物动力学特征。 Objective: To study the plasma concentration and pharmacokinetics of Spirolid injection in rats. Methods: The plasma concentrations of streptozotocin at different time points were measured at low, middle and high dose (50, 100, 200 mg · kg -1) by injection into the tail vein of rats. The pharmacokinetic parameters were also estimated. Results: The main Pharmacokinetic parameters t_ (1/2) were 0.43, 0.37 and 0.41 h after single intravenous injection of Sprague; AUC_ ((0 ~ ∞)) were 91.12, 172.65 and 280.02 mg · h · L -1 and C max were 261.23, 433.79 and 751.22 mg · L -1, respectively. Conclusion: This method is suitable for pharmacokinetic study. Spirobuter injections in rats showed linear pharmacokinetic profiles over the 50-200 mg dose range.