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β细胞中葡萄糖升高致ＡＴＰ ＡＤＰ比值升高 ,从而关闭Ｋ通道导致细胞去极化 ,Ｃａ2 + 内流使胰岛素分泌而降低血糖。因而人们推测基因突变致β细胞中ＫＡＴＰ 通道对ＡＴＰ ＡＤＰ升高的敏感性降低 ,继而胰岛素分泌不足而致糖尿病。方法与设计 构建突变ＫＡＴＰ 基因质粒重?
Increased glucose in beta cells leads to an increase in the ratio of ATP to ADP, which in turn leads to depolarization of the K-channel and Ca2 + influx to insulin secretion and lower blood glucose. Therefore, it is hypothesized that the KATP channel in β-cells in which the gene mutation causes β-cells is less sensitive to the elevation of ATP-ADP, which in turn leads to insufficient insulin secretion resulting in diabetes. Methods and Design Construction of Mutant KATP Gene Plasmid?