1995年Meunier和Reinscheid等几乎同时从脑组织中分离出一种新的由17个氨基酸组成的肽—孤啡肽(OFQ)或痛敏肽,并证明孤啡肽特异性结合阿片样受体(opioid-like receptor 1,OLR1)为OFQ的同源性配体。由于孤啡肽前体的分子结构与阿片类前体,如强啡肽和脑啡肽原的前体分子有很高的同源性。因此,它也可能有着巨大的潜在生物学功能。为此,许多学者作了大量的研究工作,现就其近年来的研究进展综述如下。 In 1995, Meunier and Reinscheid et al. Isolated a new 17-amino acid peptide (OFQ) or nociceptin from brain tissue almost simultaneously and demonstrated that orphanin binds specifically to opioid receptors opioid-like receptor 1, OLR1) is a homologue of OFQ. Since the molecular structure of orphanin precursor has high homology with opioid precursors, such as proenorphin and proenkephalin precursor molecules. Therefore, it may also have tremendous potential biological function. To this end, many scholars have done a lot of research work, and now their research progress in recent years are summarized below.