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对２９例血压正常、多次尿蛋白定性阴性的早期ＮＩＤＤＭ患者在用巯甲丙脯酸（ＣＰＴ）治疗２周前、后的肾血流动力学及肾前列腺素的变化进行了观察。结果表明ＮＩＤＤＭ早期存在肾小球滤过率（ＧＦＲ）、滤过分数（ＦＦ）以及肾前列环素（ＰＧＩ２）的增加，ＣＰＹ治疗后，选择性地降低了患者ＧＦＲ、ＦＦ及肾ＰＧＩ２，同时减少了尿微白蛋白的排泄。提示ＣＰＴ对早期糖尿病肾病的防治具有重要意义。
Renal hemodynamics and renal prostaglandin changes were observed in 29 patients with normotensive and multiple negative urinary protein in the early stage of NIDDM after 2 weeks of treatment with captopril (CPT). The results showed that glomerular filtration rate (GFR), filtration fraction (FF) and increase of prostacyclin (PGI2) in early stage of NIDDM increased GFR, FF and PGI2 in the kidney of patients after CPY treatment, Reduce urinary microalbumin excretion. Tip CPT on the prevention and treatment of early diabetic nephropathy is of great significance.