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目的：探讨羟基脲联合化疗治疗高白细胞性急性白血病的疗效。方法：观察组22例化疗前服用羟基脲与别嘌醇，其后采用诱导缓解治疗；对照组单用化疗，方案和剂量同治疗组。结果：观察组白细胞中位数下降至13 ×109／L[（2．0 ～21．3）×109／L]，高黏滞综合征症状明显改善或消失，观察组完全缓解率和有效率显著高于对照组（P ＞0．05）。结论：羟基脲联合化疗治疗高白细胞性白血病疗效确切，优于常规化疗方法。
Objective: To investigate the efficacy of hydroxyurea combined with chemotherapy in the treatment of high leukemia acute leukemia. Methods: Twenty-two patients in the observation group were treated with hydroxyurea and allopurinol before chemotherapy, followed by induction of remission therapy. The control group was treated with chemotherapy, regimen and dose alone. Results: The median leukocyte count decreased to 13 × 109 / L [(2.0 ~ 21.3) × 109 / L] in the observation group. The symptoms of hyperviscosity syndrome obviously improved or disappeared. The complete remission rate and the effective rate Significantly higher than the control group (P> 0.05). Conclusion: Hydroxyurea combined with chemotherapy is effective in treatment of high leukemia, which is superior to conventional chemotherapy.