52例耐烷化剂和VAD方案多发性骨髓瘤(MM)患者采用环磷酰胺(CTX)和鬼臼乙叉甙(VP_(16))方案化疗。复发12例,耐药40例;按Durie和salmon分期Ⅲ、Ⅱ和Ⅰ期分别为23、22和7例。治疗条件为:年龄≤70岁,Zubrod机能状态<3,心肺机能正常,血肌酐≤265mmol/L。该方案为:CTX600mg/m~2,VP_(16)180mg/m~2连续静滴5天,GM-CSF0.125mg/m~/d皮下注射第6天开始至粒细胞≥ Cyclophosphamide (CTX) and etoposide (VP_ (16)) regimen were used in 52 patients with alkylating agents and VAD regimen in patients with multiple myeloma (MM). Recurrence in 12 cases, resistant to 40 cases; by Durie and salmon stage Ⅲ, Ⅱ and Ⅰ were 23,22 and 7 cases. Treatment conditions: age ≤ 70 years, Zubrod functional status <3, normal heart and lung function, serum creatinine ≤ 265mmol / L. The protocol was as follows: CTX600mg / m ~ 2, VP16mg 180mg / m ~ 2 continuous infusion for 5 days, GM-CSF0.125mg / m ~ / d subcutaneous injection on the sixth day until granulocyte≥