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本研究主要观察暂时性阻断肝静脉下行肝动脉栓塞（ＴＨＡＥ－ＴＨＶＯ）后的病理改变。８只犬进行了ＴＨＡＥ－ＴＨＶＯ。治疗时在球囊导管完全阻断相应区域肝静脉下向肝动脉注入超液化碘油，然后注入明胶海绵碎片；对照组４只，仅做肝动脉栓塞（ＴＨＡＥ）。术后观察１～８周，复查肝功能、ＣＴ，间隔１～２周处死动物行病理学检查。ＴＨＡＥ－ＴＨＶＯ与ＴＨＡＥ后肝功能指标（ＡＳＴ，ＡＬＴ）均呈一过性增高，二组间差别无显著性意义。术后３周ＣＴ检查，ＴＨＡＥ－ＴＨＶＯ组碘油呈大片状或近似肝段分布，部分门脉分支内有碘油沉积；对照组仅见散在小点碘油沉积。病理检查：ＴＨＡＥ－ＴＨＶＯ后坏死范围较大，呈楔状或扇形分布，肝窦、门静脉小分支及小动脉内可见碘油颗粒。对照组见散在灶性坏死。ＴＨＡＥ－ＴＨＶＯ后栓塞区坏死范围较大，门脉小分支内有碘油者比例较高，这些改变有利于提高对肝肿瘤的治疗效果
This study mainly observed the pathological changes after transiently blocking hepatic artery embolization (THAE-THVO). Eight dogs performed THAE-THVO. During the treatment, hyperlipidic lipiodol was injected into the hepatic artery with the balloon catheter completely blocked in the corresponding region, and then gelatin sponge pieces were injected. In the control group, only 4 rabbits were treated with hepatic artery embolization (THAE). After 1 to 8 weeks of observation, liver function and CT were reexamined. Animals were sacrificed 1 to 2 weeks before pathological examination. After THAE-THVO and THAE, liver function indexes (AST, ALT) showed a transient increase. There was no significant difference between the two groups. After 3 weeks of CT examination, lipiodol in the THAE-THVO group showed a large patch or near liver segment distribution, and some of the portal vein branches contained iodized oil; only a small amount of iodized oil was found in the control group. Pathological examination: After THAE-THVO, the necrosis range was relatively large, showing a wedge-shaped or fan-shaped distribution. Lipiodol granules were observed in the hepatic sinusoids, small branches of the portal vein, and small arteries. The control group had scattered focal necrosis. THAE-THVO has a large area of necrosis in the posterior embolization area and a high proportion of iodized oil in the small branches of the portal vein. These changes are beneficial to improve the therapeutic effect on liver tumors.