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目的观察急性冠状动脉综合征(ACS)患者血清中单核细胞趋化蛋白-1(MCP-1)的水平与侧支形成的关系探讨其产生的可能机制。方法入选2010年6月-2011年8月间于太原市中心医院心内科行冠脉造影术的患者153例,所有患者行冠脉造影前抽动脉血标本。患者分为急性冠脉综合征组、稳定型心绞痛(SAP)组和正常对照组,急性冠脉综合征组按Rentrop’s分级法分为有侧枝组和无侧枝组,以ELISA法测定血清MCP-1浓度。结果 MCP-1浓度在急性冠脉综合征组较稳定型心绞痛组及正常对照组高(P<0.01),稳定型心绞痛组与对照组血清MCP-1浓度比较差异无统计学意义(P>0.05),急性冠脉综合征组中有侧支组的MCP-1浓度较无侧支组高,且MCP-1浓度与Rentrop’s分级存在正相关(r=0.591,P<0.01)。结论 MCP-1可预测急性冠脉综合征的发生,MCP-1对冠脉侧支形成可能起促进作用。
Objective To investigate the relationship between the level of monocyte chemoattractant protein-1 (MCP-1) and collateral formation in patients with acute coronary syndrome (ACS) and to explore the possible mechanism. Methods Totally 153 patients undergoing coronary angiography at the Central Hospital of Taiyuan Central Hospital between June 2010 and August 2011 were enrolled. All patients underwent coronary arteriography. Patients were divided into acute coronary syndrome group, stable angina pectoris (SAP) group and normal control group. The acute coronary syndrome group was divided into collateral group and collateral group by Rentrop’s grading method. Serum MCP-1 concentration. Results The concentration of MCP-1 in acute coronary syndrome group was higher than those in stable angina group and normal control group (P <0.01), and there was no significant difference in serum MCP-1 concentration between stable angina pectoris group and control group (P> 0.05 ). The concentration of MCP-1 in collaterals group was significantly higher than that in non-collateral group in acute coronary syndrome group. There was a positive correlation between MCP-1 concentration and Rentrop’s grade (r = 0.591, P <0.01). Conclusion MCP-1 can predict the occurrence of acute coronary syndrome, MCP-1 may promote the formation of coronary collaterals.