论文部分内容阅读
本实验应用改良的八木国夫法和联大菌香胺法测定了65名肺心病急性加重期病人的血浆脂质过氧化物(LPO)和红细胞超氧化物歧化酶(SOD)的含量。并对它们两者的改变与营养及肺功能的关系进行了多元回归分析,结果显示:肺心病急性加重期病人血浆LPO水平明显上升(P<0.01),红细胞SOD水平显著下降(P<0.01),与正常对照组相比,LPO、SOD比例显著异常,LPO和SOD与整体营养参数显著相关(P<0.01),其中与肌酐/身高指数[CHI]对LPO的影响显著。SOD则受整体参数的作用。LPO、SOD分别与肺功能(包括血气),综合参数容均相关(P<0.01),其中以VC％对LPO水平作用显著。上述结果表明:肺心病急性加重期病人体内氧化与抗氧化系统显著失衡,并与病情的严重程度密切相关,营养不良是这种异常发生的重要机制之一。
In this study, 65 patients with acute exacerbation of cor pulmonale were used to determine the levels of plasma lipid peroxides (LPO) and erythrocyte superoxide dismutase (SOD) in patients with improved Yagi-Guofu and URSA methods. Multiple regression analysis was conducted on the relationship between changes in both of them and nutrition and pulmonary function. The results showed that the level of LPO in patients with acute exacerbation of pulmonary heart disease increased significantly (P <0.01) and the level of SOD in erythrocytes decreased significantly (P <0.01) (P <0.01). LPO and creatinine / height index [CHI] had a significant effect on LPO. Compared with normal control group, LPO and SOD were significantly abnormal. LPO and SOD were significantly correlated with overall nutrition parameters. SOD is affected by the overall parameters. LPO and SOD were correlated with pulmonary function (including blood gas) and comprehensive parameters respectively (P <0.01). The effect of VC% on LPO level was significant. The above results show that: in patients with acute exacerbation of pulmonary heart disease, there is a significant imbalance between the oxidation and anti-oxidant system in the patient, which is closely related to the severity of the disease. Malnutrition is one of the important mechanisms of this abnormality.