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目的 :观察中风通络丸抗脑缺血的作用,为其临床用药提供实验依据。方法 :各组雄性SD大鼠采用线栓法复制局灶性脑缺血模型,造模后各组大鼠继续给药3d。于造模后24h及末次给药后次日,对各组大鼠进行神经功能评分,麻醉取脑,TTC染色,测量梗死面积并计算梗死率。结果 :中风通络丸中、高剂量组能显著降低大鼠脑缺血模型神经功能评分等级,显著减少脑缺血所致的脑梗死面积百分比。结论 :中风通络丸能明显改善脑缺血大鼠神经功能症状,降低脑脏器系数及脑梗死面积百分比,具有明显抗脑缺血作用。
Objective: To observe the effect of Zhongfeng Tongluo pill on cerebral ischemia and provide experimental evidence for its clinical use. Methods: Focal cerebral ischemia model was induced by suture method in each group of male SD rats. Neurological function scores of rats in each group were scored 24 h after the modeling and the next day after the last administration. Brain tissue was stained with TTC and infarction area was measured and infarction rate was calculated. Results: Zhongfeng Tongluo Pills medium and high dose group can significantly reduce the level of neurological function in rat model of cerebral ischemia, significantly reduce the percentage of cerebral infarction caused by cerebral ischemia. Conclusion: Zhongfeng Tongluo Pill can significantly improve the neurological deficits in cerebral ischemic rats, decrease the percentage of cerebral organ coefficient and area of cerebral infarction, and have obvious anti-ischemic effect.