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目的研究2型糖尿病与脂联素基因及行为因素的相互关系。方法对上海市浦东新区常住居民中新发糖尿病病人(糖尿病组)及社区正常人群(对照组)各590人进行病例-对照研究,利用单因素和多因素非条件Logistic回归分析。结果脂联素SNP+276三种基因型和等位基因分布差异有统计学意义,糖尿病组中G/G基因型多于对照人群。通过单因素分析显示,SNP+276、职业体力活动、每周锻炼时间、饮酒与糖尿病关系有统计学意义。通过多因素分析显示,职业体力活动、休闲体力活动、每周锻炼时间、饮酒等指标均有统计学意义,其中休闲时体力活动是2型糖尿病的保护因素,同时脂联素SNP+276与每周锻炼时间交互作用有统计学意义,较长锻炼时间能使糖尿病患病风险降低。结论脂联素基因、行为因素均与2型糖尿病有关,同时二者存在交互作用。
Objective To study the relationship between type 2 diabetes and adiponectin gene and behavioral factors. Methods A case-control study was conducted on 590 newly diagnosed diabetes mellitus patients (DM group) and 5 normal community residents (control group) in the permanent residents of Pudong New Area, Shanghai. Single-factor and multivariate non-conditional logistic regression analysis were performed. Results There were significant differences in the distribution of three genotypes and alleles of adiponectin SNP + 276. There were more G / G genotypes in diabetic group than in control group. By univariate analysis, SNP + 276, occupational physical activity, weekly exercise time, alcohol consumption and diabetes were statistically significant. Multivariate analysis showed that occupational physical activity, leisure physical activity, exercise time per week, alcohol consumption and other indicators were statistically significant, of which physical activity during leisure is a protective factor for type 2 diabetes, and adiponectin SNP + 276 with each Week exercise time interaction was statistically significant, longer exercise time can reduce the risk of diabetes. Conclusions Adiponectin gene and behavioral factors are all associated with type 2 diabetes mellitus, both of which interact with each other.