目的观察米力农在重症手足口病(HFMD)并发心血管损害患者中的治疗效果。方法对64例重症HFMD合并心血管损害的患儿随机平分为A、B两组,两组均给予甲基泼尼松龙、静脉用免疫球蛋白、病毒唑、果糖二磷酸钠和其他常规性治疗,其中B组在此基础上加用米力农治疗,A组未用米力农,观察两组血压、心率及心肌酶的变化情况。结果两组比较差异具有统计学意义(P<0.05)。结论对HFMD并发心血管损害的患儿可早期应用甲基泼尼松龙、静脉用免疫球蛋白、病毒唑、果糖二磷酸钠等治疗,对有血压升高、心率增快的患儿加用米力农治疗,疗效显著。 Objective To observe the therapeutic effect of Milrinone in patients with severe hand-foot-mouth disease (HFMD) complicated with cardiovascular damage. Methods Sixty-four children with severe HFMD complicated with cardiovascular damage were divided into two groups randomly. The two groups were given methylprednisolone, intravenous immunoglobulin, ribavirin, sodium fructose diphosphate and other routine Treatment, in which B group on this basis with Milrinone treatment, A group did not use Milrinone, blood pressure, heart rate and myocardial enzyme changes in both groups. Results The difference between the two groups was statistically significant (P <0.05). Conclusions In children with HFMD complicated by cardiovascular damage, methylprednisolone, intravenous immunoglobulin, ribavirin and sodium fructose diphosphate can be used in early stage of HFMD. Children with elevated blood pressure and heart rate can be treated with Milrinone treatment, a significant effect.