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目的探讨高选择性α-受体阻断药萘哌地尔联合左氧氟沙星对留置D-J管所致不良反应的疗效。方法行输尿管镜气压弹道碎石术(URL)后常规留置D-J管的输尿管结石患者59例,随机分为治疗组29例,对照组30例。治疗组给予萘哌地尔分散片25 mg,qn,同时加服盐酸左氧氟沙星分散片0.2 g,q12h。对照组口服盐酸左氧氟沙星分散片0.2 g,q12h。观察疼痛模拟评分(VAS)、膀胱过度活动症状评分(OABSS)、生活质量评分(QOL)、最大尿流率(Qmax)及血压变化等指标。结果治疗组和对照组Qmax分别为(15.79±1.96),(10.70±1.53)mL·s-1(P<0.01);治疗组VAS、OABSS、QOL均小于对照组(均P<0.01);两组白细胞计数、血压变化均差异无统计学意义(P>0.05)。结论萘哌地尔联合左氧氟沙星可治疗URL后留置D-J管出现的不良反应,显著缓解患者相关症状及改善生活质量,无明显不良反应。
Objective To investigate the curative effect of high selective α-blocker naftopidil combined with levofloxacin on adverse reactions induced by indwelling D-J tube. Methods Fifty-nine patients with ureteral calculi with conventional D-J tube after ureteroscopic pneumatic lithotripsy (URL) were randomly divided into treatment group (n = 29) and control group (n = 30). The treatment group was given Naftopidil dispersible tablets 25 mg, qn, plus levofloxacin hydrochloride tablets 0.2 g, q12h. Control group oral levofloxacin tablets 0.2 g, q12h. VAS score, OABSS, QOL, Qmax and blood pressure were observed. Results The Qmax of the treatment group and the control group were (15.79 ± 1.96) and (10.70 ± 1.53) mL · s-1 respectively (P <0.01). The VAS, OABSS and QOL of the treatment group were lower than those of the control group There was no significant difference in the white blood cell count and blood pressure between the two groups (P> 0.05). Conclusion Naftopidil combined with levofloxacin can treat postoperative adverse reactions of D-J tube left after URL, significantly relieve the symptoms and improve the quality of life of patients with no obvious adverse reactions.