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目的探讨去整合素基质金属蛋白酶19(ADAM19)与子宫内膜癌的发生、发展、浸润及转移的关系。方法选择2002年2月至2010年8月在广西医科大学第一附属医院妇科行手术治疗的患者共81例为研究对象,采用免疫组织化学的检测方法测定50例子宫内膜癌组织,16例不典型增生子宫内膜组织以及15例正常增殖期子宫内膜组织中ADAM19的表达情况,并分析其表达与各种临床参数的关系。结果 ADAM19蛋白在正常子宫内膜组织、不典型增生子宫内膜组织和子宫内膜癌组织中的高表达率分别为26.7%、75.0%和64.0%。在子宫内膜癌组织中的ADAM19的表达明显高于正常子宫内膜,差异有统计学意义(P<0.05)。ADAM19的表达与子宫内膜癌的组织学分级、肌层浸润深度、患者是否绝经有关(P<0.05),与子宫内膜癌的临床分期、淋巴结转移无关(P>0.05)。结论 ADAM19与子宫内膜癌的发生发展相关。
Objective To investigate the relationship between the expression of integrin matrix metalloproteinase 19 (ADAM19) and the occurrence, development, invasion and metastasis of endometrial carcinoma. Methods A total of 81 patients undergoing gynecological surgery at the First Affiliated Hospital of Guangxi Medical University from February 2002 to August 2010 were enrolled in this study. Immunohistochemistry was used to detect 50 cases of endometrial cancer and 16 cases of endometrial cancer Dysplasia and endometrial tissue of 15 cases of normal proliferative endometrium ADAM19 expression and analysis of its expression and the relationship between various clinical parameters. Results The high expression rates of ADAM19 protein in normal endometrial tissues, atypical hyperplasia endometrial tissues and endometrial carcinoma tissues were 26.7%, 75.0% and 64.0%, respectively. The expression of ADAM19 in endometrial carcinoma was significantly higher than that in normal endometrium, the difference was statistically significant (P <0.05). The expression of ADAM19 was correlated with histological grade, depth of myometrial invasion, and whether the patient was menopausal (P <0.05), but not with clinical stage and lymph node metastasis of endometrial carcinoma (P> 0.05). Conclusion ADAM19 is associated with the occurrence and development of endometrial cancer.