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关于何杰金氏病究竟起源于淋巴细胞还是巨噬细胞目前仍有争论,最近有些研究支持何杰金氏病的恶性细胞来自巨噬细胞。作者对42例未治疗过的何杰金氏病患者以溶菌法和特异的免疫学方法测定了血浆溶菌酶。结果除4例血浆溶菌酶为正常外,其余均增加。平均值为5.9微克/毫升±1.8(S.D),正常值为2.4微克/毫升±0.6,各病期的血浆溶菌酶为:Ⅰ期、5.0微克/毫升±0.9(S.D),Ⅱ期,5.3微克/毫升±1.8,Ⅲ期,5.9微克/毫升±1.8、Ⅳ期,7.7微克/毫升±1.7。除第Ⅳ期有明显增高外,前三期无明显差异。此外有症状的患者比无症状者明显增加(6.4毫克/毫升±2.0,对5.2微克/毫升±1.3,P<0.01)。血浆溶菌酶值和组织学类型之间无关系。血液中粒细胞和单核细胞计数也与溶菌酶值无关系
It is still debated whether Hodgkin’s disease originates from lymphocytes or macrophages. Recently, some studies support that Hodgkin’s disease’s malignant cells are derived from macrophages. The authors tested plasma lysozyme in 42 untreated Hodgkin’s patients using lysozyme and specific immunological methods. Results In addition to 4 cases of plasma lysozyme normal, the rest were increased. Mean values were 5.9 μg / ml ± 1.8 (SD), normal values were 2.4 μg / ml ± 0.6, plasma lysozyme at various stages was stage Ⅰ, 5.0 μg / ml ± 0.9 SD, / Ml ± 1.8, stage Ⅲ, 5.9 μg / ml ± 1.8, stage IV, 7.7 μg / ml ± 1.7. Except for the significant increase in stage IV, there was no significant difference in the first three stages. In addition, the number of symptomatic patients was significantly higher than asymptomatic patients (6.4 mg / mL ± 2.0, vs 5.2 μg / mL ± 1.3, P <0.01). There was no relationship between plasma lysozyme value and histological type. Neutrophils and monocyte counts in the blood also did not correlate with lysozyme values