目的　探讨阿奇霉素序贯疗法治疗小儿支原体肺炎的疗效。方法　选择符合诊断标准的支原体肺炎患儿 72例 ,随机分为两组 ,观察组及对照组各 36例。观察组先静滴红霉素 ,4d后改为阿奇霉素口服 ;对照组用阿奇霉素 10mg·kg-1·d-1静脉滴注。观察两组临床疗效、住院时间、住院费用等。结果　两组在治疗效果上无明显差异 (P >0 0 5 ) ,但在住院日、住院费用方面 ,观察组明显优于对照组 (P <0 0 1)。结论　阿奇霉素序贯疗法治疗小儿支原体肺炎是可行的 ,疗效是可靠的 ,值得临床推广。 Objective To investigate the curative effect of sequential treatment of azithromycin on children with mycoplasma pneumonia. Methods 72 cases of children with mycoplasmal pneumonia who meet the diagnostic criteria were randomly divided into two groups, 36 cases in observation group and control group. The observation group first intravenous erythromycin, 4d after azithromycin oral; control group with azithromycin 10mg · kg-1 · d-1 intravenous infusion. The clinical efficacy, hospitalization time and hospitalization cost of the two groups were observed. Results There was no significant difference between the two groups in the treatment effect (P> 0.05). However, the observation group was significantly better than the control group in hospitalization days and hospitalization costs (P <0.01). Conclusion Sequential azithromycin treatment of children with mycoplasma pneumonia is feasible, the effect is reliable and worthy of clinical promotion.