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16头猪分G1组（ARDS，n=4）、G2组（ARDS＋NO，n=4、G3组（对照＋NO，n＝4）和G4组（对照，n=4）。静脉输注铜绿假单胞菌制备ARDS模型，对照组输注生理盐水。一氧化氮（NO）输送装置释放40ppmNO。结果：G1组发生肺动脉高压，肺内分流增加，低氧血症；G2组肺动脉压较G1组明显下降（P＜0．05）而血压和G1组无差异，分流减少，氧合增加；G3、G4组无明显改变。结论：吸入40ppmNO能选择性降低脓毒性ARDS的肺动脉高压，减少肺内分流，增加氧合。
16 pigs were divided into G1 group (ARDS, n = 4), G2 group (ARDS + NO group, n = 4, G3 group and G4 group, n = 4) The control group was infused with normal saline, nitric oxide (NO) delivery device was used to release 40 ppm NO.Results: In group G1, pulmonary hypertension occurred, pulmonary shunt increased, and hypoxemia. Compared with G1 group, the pulmonary arterial pressure in G2 group was significantly higher (P <0.05), but there was no difference between blood pressure and G1 group, the shunt decreased and the oxygenation increased, but there was no significant change in G3 and G4 group.Conclusion: Inhalation of 40ppmNO can selectively reduce the pulmonary hypertension in septic ARDS and reduce the intrapulmonary shunt , Increase oxygenation.