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本文分析了153例雷诺现象患者的临床诊断和表现,以关节炎、肌炎和手肿胀发病率高,分别为86.9%、35.5%和31.4%;血清中自身抗体阳性率最高的是抗RNP抗体(71.2%),其次是抗Sm抗体(38.5%)和抗dsDNA抗体(37%)。在SLE患者中,雷诺现象阳性组(79例)患者的手肿胀,抗RNP抗体和抗Sm抗体的阳性率高于雷诺现象阴性组(145例)患者(P<0.005)。讨论了抗RNP抗体和抗Sm抗体雷诺中现象在的发病机理作用。
This article analyzes 153 cases of Renault phenomenon in patients with clinical diagnosis and performance, with arthritis, myositis and swollen hand swelling rates were 86.9%, 35.5% and 31.4% respectively; serum autoantibodies are the highest positive rate of anti-RNP antibodies (71.2%), followed by anti-Sm antibody (38.5%) and anti-dsDNA antibody (37%). In SLE patients, the positive rate of hand swelling, anti-RNP antibodies and anti-Sm antibodies in patients with Renault-positive group (79 patients) was higher than that in patients with negative Renault group (145 patients) (P <0.005). The pathogenesis of anti-RNP antibodies and anti-Sm antibodies in Reynolds was discussed.