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目的探讨IL-16、IL-18在过敏性紫癜患儿中的应用价值。方法采用固相酶联免疫分析法检测50例过敏性紫癜患儿血清IL-16、IL-18水平。结果过敏性紫癜急性期患儿血清IL-16、IL-18较健康对照组明显升高(0.05),过敏性紫癜患儿IL-16与IL-18呈正相关性。结论 IL-16、IL-18可能参与过敏性紫癜血管炎的发病,IL-16、IL-18的检测与过敏性紫癜病情发展有一定的关系。“,”Objective To investigate the application value of IL-16,IL-18 in children with Henoch Schonlein purpura. Methods Analysis of 50 cases of al ergic purpura in children with serum IL-16,IL-18 levels by solid phase enzyme immunoassay. Results Henoch Schonlein purpura in acute phase serum IL-16,in IL-18 patients than in the healthy control group significantly increased ( O.05),al ergic purpura Hui son IL-16 was positively cor elated with IL-18.Conclusion IL-16,IL-18 may be involved in the pathogenesis of vasculitis al ergic purpura,there is some relationship between the detection of IL-16,IL-18 and al ergic purpura disease development.