近来,生物起搏逐渐成为心脏起搏治疗研究的新热点。目前国内外研究已取得一定进展:包括利用基因工程增加细胞舒张期内向电流、降低细胞复极电流、增加4期除极速度以提高心肌细胞自律性;利用不同起搏细胞移植技术进行修复或替代心脏起搏或传导细胞;以及基因和细胞技术的联合来达到生物起搏的目的。但各种研究手段尚存在的不足,如:稳定性差、持续时间短、调控困难、安全性低等问题尚待解决。 Recently, biological pacing has gradually become a new hotspot in the research of cardiac pacing therapy. At present, some progress has been made in the research at home and abroad, including the use of genetic engineering to increase the inward current of diastolic cells, decrease the repolarization current of cells, increase the depolarization speed of the fourth phase to improve the cardiomyocyte autonomy, repair or replace with different pacemaker cell transplantation techniques Heart pacing or conduction of cells; and gene and cell technology to achieve the purpose of biological pacing. However, there are still some shortcomings in various research methods, such as poor stability, short duration, difficulty in regulation and control and low safety.