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目的分析胃肠道神经内分泌肿瘤的临床表现和病理特点,研究新的病理学分类方法,以提高对该类疾病的认识。方法回顾性分析病理证实为神经内分泌肿瘤的胃肠道病变32例,对肿瘤进行常规镜检,并做免疫组化检测。比较不同类型肿瘤的发病年龄、分布部位、临床表现及组织病理特征。结果 32例患者可分为4型:高分化神经内分泌肿瘤G112例、高分化神经内分泌肿瘤G29例、神经内分泌癌9例和混合性腺神经内分泌癌2例。其中来自前肠15例,中肠8例,后肠9例。不同类型胃肠道神经内分泌肿瘤的病理表现各有不同。结论胃肠道神经内分泌肿瘤临床表现不典型,病理学诊断是其最后确诊的主要方法,免疫组化的合理应用可提高神经内分泌癌的诊断率新的病理学分类方法更加客观准确。
Objective To analyze the clinical manifestations and pathological features of gastrointestinal neuroendocrine tumors and to study new pathological classification methods to improve the understanding of these diseases. Methods Retrospective analysis of pathological confirmed neuroendocrine tumors in 32 cases of gastrointestinal lesions, the conventional microscopic examination of the tumor, and immunohistochemical detection. The age, distribution, clinical manifestations and histopathological features of different types of tumors were compared. Results 32 patients were divided into 4 types: G112 cases of well-differentiated neuroendocrine tumors, G29 cases of well-differentiated neuroendocrine tumors, 9 cases of neuroendocrine carcinoma and 2 cases of mixed glandular neuroendocrine carcinoma. Among them, 15 cases came from the foregut, 8 cases from the midgut and 9 cases from the hindgut. Different types of gastrointestinal neuroendocrine tumors have different pathological manifestations. Conclusion The clinical manifestations of gastrointestinal neuroendocrine tumors are not typical. Pathological diagnosis is the main method of final diagnosis. The rational application of immunohistochemistry can improve the diagnostic rate of neuroendocrine carcinoma. The new pathological classification method is more objective and accurate.