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目的探讨和分析药物性肝损伤的临床特点及其发病规律。方法对我院38例药物性肝损伤患者的病因进行回顾性分析,研究其治疗所用药物、临床表现以及转归。结果引起患者肝损伤的药物种类非常多,居首位的是肿瘤化疗,其次为解热镇痛药,第三是抗结核药。肝损伤患者临床表现没有特异性,主要表现包括乏力、纳差、尿黄以及肝区不适。38例患者中有6例患者仅有实验室检测异常,经正规治疗之后,药物性肝损伤在30d内降低了50%以上,没有1例患者死亡。结论肿瘤化疗药、解热镇痛药和抗结核药是引起药物性肝损伤的主要病因,其临床表现没有特异性,预后较好,医生在用药时应注意监测患者肝功能。
Objective To investigate and analyze the clinical features and pathogenesis of drug-induced liver injury. Methods The etiology of 38 patients with drug-induced liver injury in our hospital were retrospectively analyzed to study the drugs used in the treatment, clinical manifestations and outcomes. The results of patients with liver injury caused by many types of drugs, the first place is the tumor chemotherapy, followed by antipyretic analgesics, the third is anti-TB drugs. The clinical manifestations of liver injury patients are not specific, the main manifestations include fatigue, anorexia, urinary yellow and liver discomfort. Six of the 38 patients had only laboratory abnormalities. After formal treatment, drug-induced liver injury was reduced by more than 50% within 30 days and none of the patients died. Conclusions Tumor chemotherapeutic drugs, antipyretic and analgesic drugs and anti-TB drugs are the main causes of drug-induced liver injury. The clinical manifestations are not specific and the prognosis is good. The doctor should pay attention to monitor the liver function of patients when using drugs.