论文部分内容阅读
目的:研究草棉花花瓣采用不同工艺提取的产物提取物Ⅰ和提取物Ⅱ(FGF-Ⅰ、FGF-Ⅱ)对扑热息痛引起的实验性肝损伤是否有保护作用。方法:选用昆明种小鼠,采用腹腔注射扑热息痛的方法造成肝损伤动物模型;观察FGF-Ⅰ和FGF-Ⅱ对血清谷丙转氨酶(ALT)、谷草转氨酶(AST)活性及肝组织匀浆超氧化物歧化酶(SOD)、丙二醛(MDA)、谷胱甘肽过氧化物酶(GSH-PX)水平的影响。结果:FGF-Ⅰ和FGF-Ⅱ对小鼠血清ALT、AST活性均有降低作用。FGF-Ⅰ对肝组织SOD、GSH-PX活性没有影响,但可以降低肝组织MDA含量。FGF-Ⅱ可以增加肝组织SOD活性、降低MDA含量、增加GSH-PX活性。结论:FGF-Ⅰ和FGF-Ⅱ均有一定的保肝作用,但是FGF-Ⅱ作用优于FGF-Ⅰ。
OBJECTIVE: To study whether the product extract I and extract II (FGF-I, FGF-II) extracted from the petals of cotton grass have different protective effects on paracetamol-induced experimental hepatic injury. METHODS: Animal models of hepatic injury were induced by intraperitoneal injection of paracetamol in Kunming mice. The activity of ALT and AST in serum and the hyper-oxidation of liver homogenate were observed by FGF-I and FGF-II. The effects of SOD, MDA, and GSH-PX levels. RESULTS: FGF-I and FGF-II all reduced the serum ALT and AST activity in mice. FGF-I had no effect on SOD, GSH-PX activity in liver tissue, but it could reduce MDA content in liver tissue. FGF-II can increase SOD activity, decrease MDA content and increase GSH-PX activity in liver tissue. Conclusion: Both FGF-I and FGF-II have a certain hepatoprotective effect, but FGF-II is better than FGF-I.