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1904年Bohr发现血红蛋白-氧(Hb-O_2)正常的离解曲线为一S形曲线,H~+使曲线左移或右移的现象称Bohr效应。此后氧离曲线对氧运输的影响逐渐引起生理学者的重视,许多学者研究pH、PCO_2及温度与氧离曲线的位置关系,也发现疾病及高原环境使曲线位置偏移。如1917年Hasselbalch报道8例恶性贫血、尿毒症、痛风和糖尿病昏迷患者,有5例氧离曲线位置异常。此后这方面的研究进展甚少。1967年Benesch和Chanutin发现红细胞内有机磷化合物,主要是
In 1904, Bohr found that the normal dissociation curve of hemoglobin-oxygen (Hb-O 2) was an S-shaped curve, and that of H ~ + shifted the curve to the left or right was called the Bohr effect. Since then, the effect of oxygen dissociation curve on oxygen transport gradually attracted the attention of the physiologists. Many scholars studied the relationship between pH, PCO 2 and temperature and oxygen ion curve, and also found that the disease and plateau environment shifted the position of the curve. As reported by Hasselbalch in 1917, eight patients with pernicious anemia, uremia, gout, and diabetes coma experienced an abnormal oxygen ionization curve. Since then, little progress has been made in this aspect. In 1967 Benesch and Chanutin found that intracellular red phosphorus organic compounds, mainly