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p27是一种周期素依赖激酶(CDK)抑制剂,调节细胞周期G1到S期的进程。有报道在肿瘤病人中p27低表达与生存率下降相关,然而在头颈肿瘤中没有类似的报道。作者用免疫组化和Western blot分析法调查舌鳞状细胞癌病人中p27是否与预后相关。 1982～1995年,日本滨松医科大学五官科收治的94例舌鳞状细胞癌病人全部接受根治性治疗,病人的年龄、性别、吸烟史、饮酒史、多原发灶表现、肿
p27 is a cyclin dependent kinase (CDK) inhibitor that regulates the progression from G1 to S phase of the cell cycle. It has been reported that low expression of p27 is associated with decreased survival in cancer patients, however, there is no similar report in head and neck cancer. The authors used immunohistochemistry and Western blot analysis of tongue squamous cell carcinoma in patients with p27 prognosis. From 1982 to 1995, 94 cases of squamous cell carcinoma of the tongue admitted to the Department of Etiology, Hamamatsu Medical University in Japan were all treated by radical treatment. The patients’ age, sex, smoking history, drinking history, multiple primary tumor manifestations, swollen